Peptide ke motsoako oa tlhaho, o felloang ke metsi ho tsoa ho li-amino acid 'me o na le lihlopha tsa carboxyl le amino.Ke motsoako oa amphoteric.Polypeptide ke motsoako o entsoeng ke li-amino acid tse hokahaneng hammoho ke li-bond tsa peptide.Ke sehlahisoa sa mahareng sa protheine hydrolysis.E thehoa ka ho felloa ke metsi 'meleng le condensation ea 10 ~ 100 amino acid limolek'hule,' me boima ba eona ba molek'hule bo ka tlase ho 10000Da.E ka phunyeletsa lera la semi-permeable 'me ha e tšeloe ke trichloroacetic acid le ammonium sulfate, ho kenyelletsa le li-peptide tsa bioactive le li-peptide tsa maiketsetso tsa maiketsetso.
Lithethefatsi tsa polypeptide li bua ka li-polypeptide tse nang le litlamorao tse itseng tsa kalafo ka motsoako oa lik'hemik'hale, ho kopanya liphatsa tsa lefutso le ho ntšoa ha liphoofolo le limela, tseo haholo-holo li arotsoeng ka li-polypeptides tse sa feleng (tse kang enkephalin le thymosin) le li-polypeptides tse ling tse sa tloaelehang (tse kang chefo ea noha le sialic acid).Boima bo lekantsoeng ba limolek'hule tsa lithethefatsi tsa polypeptide bo pakeng tsa lithethefatsi tsa protheine le lithethefatsi tsa micromolecule, tse nang le melemo ea lithethefatsi tsa micromolecule le lithethefatsi tsa protheine.Ha ho bapisoa le lithethefatsi tsa micromolecule, lithethefatsi tsa polypeptide li na le ts'ebetso e phahameng ea tlhaho le tse ikhethang tse matla.Ha li bapisoa le lithethefatsi tsa protheine, lithethefatsi tsa polypeptide li na le botsitso bo betere, boits'ireletso bo tlase, bohloeki bo phahameng le litšenyehelo tse tlase.
Polypeptide e ka monngoa ke 'mele ka kotloloho le ka mafolofolo,' me lebelo la ho monya le potlakile, 'me ho monya ha polypeptide ho tla pele.Ho phaella moo, li-peptide ha li khone ho jara limatlafatsi feela, empa hape li fetisetsa boitsebiso ba cellular ho laela methapo.Lithethefatsi tsa polypeptide li na le litšoaneleho tsa ts'ebetso e phahameng, khetho e phahameng, chefo e tlase le kamano e phahameng ea sepheo, empa ka nako e ts'oanang, li boetse li na le mefokolo ea halofo ea bophelo bo khuts'oane, ho fokola ha membrane ea lisele le tsela e le 'ngoe ea tsamaiso.
Ka lebaka la mefokolo ea lithethefatsi tsa polypeptide, bafuputsi ba entse matsapa a sa feleng tseleng ea ho ntlafatsa li-peptide ho ntlafatsa bioavailability ea lithethefatsi tsa polypeptide.Ho potoloha ha li-peptide ke e 'ngoe ea mekhoa ea ho ntlafatsa li-peptide, mme nts'etsopele ea li-peptide tsa cyclic e tlisitse mafube ho lithethefatsi tsa polypeptide.Li-peptide tsa cyclic li na le molemo ho meriana ka lebaka la botsitso ba tsona bo botle ba metabolic, khetho le kamano, ho kenella ha lisele tsa lisele le ho fumaneha ha molomo.Li-peptide tsa cyclic li na le mesebetsi ea tlhaho e kang anti-cancer, anti-infection, anti-fungus le anti-virus, 'me ke limolek'hule tsa lithethefatsi tse tšepisang haholo.Lilemong tsa morao tjena, litlhare tsa cyclic peptide li hohetse tlhokomelo e kholo, 'me lik'hamphani tsa meriana li latetse mokhoa o mocha oa nts'etsopele ea lithethefatsi le ho beha litsela tsa lithethefatsi tsa cyclic peptide ka ho latellana.
Dr. Chen Shiyu oa Shanghai Institute of Pharmacology, Chinese Academy of Sciences o hlahisitse lithethefatsi tsa cyclic peptide tse amohetsoeng ho tloha 2001 ho ea 2021 ka lithethefatsi tsa eona tsa cyclic peptide tse amohetsoeng litlhare tse peli tse fetileng.Lilemong tse 20 tse fetileng, ho na le mefuta e 18 ea litlhare tsa cyclic peptide 'marakeng, moo palo ea li-peptide tsa cyclic tse sebetsang ho cell wall synthesis le β-1,3- glucanase targets e kholo ka ho fetisisa, ka mefuta e 3 e 'ngoe le e 'ngoe.Lithethefatsi tse amohetsoeng tsa cyclic peptide li koahela anti-infection, endocrine, sistimi ea tšilo ea lijo, metabolism, tumor / immune system le tsamaiso ea methapo e bohareng, eo ho eona lithethefatsi tse thibelang tšoaetso le endocrine cyclic peptide li etsang karolo ea 66.7%.Mabapi le mefuta ea libaesekele, ho na le lithethefatsi tse ngata tsa cyclic peptide tse tsamaisoang ka li-bond tsa disulfide le libaesekele ka li-amide bond, 'me lithethefatsi tse 7 le 6 li ile tsa amoheloa ka ho latellana.
Nako ea poso: Sep-18-2023